The objective of this workshop is to discuss computer simulation techniques to determine the motion of biomolecules, with particular emphasis on how these methods can be extended and new methods developed to study the biologically relevant motions in large biomolecular complexes. As well as reviews of currently available methods, there will be discussions of how to best to propel this field forward, with special attention given to input assumptions, and comparison with experimental techniques. The workshop will be limited to 50 participants to encourage the easy exchange of ideas, and will include many discussion sessions, hands on demonstrations, as well as more formal talks.