Path Integral-Based Inference and Uncertainty Quantification: Reconstruction of Bond Energies and Mobility in Dynamic Force Spectroscopy

Spring 2017
Tom Chou
University of California, Los Angeles
Wed, 2017-04-26
487 GWC
Robert Ros


A Bayesian interpretation is given for regularization terms for

parameter functions in inverse problems. Fluctuations about the

extremal solution depend on the regularization terms - which encode

prior knowledge - provide quantification of uncertainty. After

reviewing a general path-integral framework, we set up a number of

applications that arise in biophysics. The inference of bond energies

and bond coordinate mobilities from dynamic force spectroscopy

experiments are worked out in detai


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