Stephen Wells
Research Associate
PhD, Cambridge, Earth Sciences (Mineral Physics), 2003
Home Department Physics
ASU Affiliations Center for Biological Physics
Areas of Study Biophysics simulations, mineral physics simulations


Background I am applying novel simulation techniques, developed on mineral frameworks, to the rapid generation of protein conformers using rigidity theory. We can now produce thousands of protein conformers, spanning several Angstroms RMS-D motion, in a matter of minutes on a single processor. Our website at FLEXWEB provides access to our FIRST5 rigidity analysis code with the FRODA mobility routine. Rapid conformer generation has applications to protein folding, structure prediction and enzyme activity. My CV and research interests are available online. I am the 700th member of the NCSE's Project Steve.

Random mobility of the protein barnase, simulated with the FIRST/FRODA algorithm (rigidity analysis + geometric simulation).

Pathway for conformational change in adenylate kinase, using geometric simulation to move between the 1AKE and 4AKE structures.
StephenWellsPicture.png
Stephen Wells
19 Lynn Close
Oxford
OX30JH, UK

phone: (480) 965-8722
fax: (480) 965-7954
email: stephen.a.wells
@asu.edu
[Publication] Stephen Wells, Scott Menor, Brandon Hespenheide and M. F. Thorpe Constrained Geometric Simulation of Diffusive Motion in Proteins Physical Biology 2, S127-S136 (2005)
[Publication] A. Sartbaeva, S.A. Wells, M.F. Thorpe, E.S. Bozin and S.J.L. Billinge Geometric modeling of perovskite frameworks with Jahn-Teller distortions: application to cubic manganites Phys. Rev. Letters. 97, 065501 (2006)
[Publication] A. Sartbaeva, S.A. Wells, M.M.J. Treacy and M.F. Thorpe The Flexibility Window in Zeolites Nature Materials 5, issue 12, 962-965 (2006)