Research Group
Postdoctoral Research Associates
Graduate Students
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Stuart Lindsay
Professor
PhD, University of Manchester, 1976
Professor
PhD, University of Manchester, 1976
| Home Department | Physics |
| ASU Affiliations | Biodesign Institute - Center for Single Molecule Biophysics |
| Areas of Study | Biophysics and Scanning Probe Microscopy |
| Link | Personal Homepage |
Background We want to understand how living things work by understanding the molecules that make cells and higher organisms function. Two main projects in the lab focus on the molecular mechanisms that control gene expression and on electron transfer in molecules involved in energy metabolism. Our gene-expression project is carried out in collaboration with the Laboratory of Receptor Biology and Gene Expression at the NIH. We use atomic force microscopy to study how chromatin (the DNA-protein complex that makes chromosomes) is altered when a model gene regulation system is "turned on" by a signaling process in a cell. Our energy transfer project is carried out in collaboration with the ASU Photosynthesis Center and Motorola. We use conducting atomic force microscopy to probe the electronic properties of single molecules. We recently solved the problem of making reliable electrical contacts to single molecules (see the paper in Science listed below). These projects are supported by other work in instrumentation and biosensors. For more details see the lab homepage. |
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Single octanedithiol molecule chemically bonded to gold nano-clusters for single molecule electronic measurements.
AFM image of chromatin from a "gene-switch" (promoter region). The thin linear portion is the DNA and the white "blobs" are the protein-DNA clusters known as nucleosomes.
[Publication]
"Electrochemical Origin of Voltage-Controlled Molecular Conductance Switching" J. He, Q. Fu, S.M. Lindsay, J.W. Ciszek and J.M. Tour ,J. Am. Chem. Soc., 2006. 128: 14828-14835.
[Publication]
"AFM imaging of protein movements: Histone H2A-H2B release during nucleosome remodeling" Bash R, Wang H, Anderson C, Yodh J, Hager G, Lindsay, SM, Lohr D FEBS Letters 580, 4757-4761 (2006).
[Publication]
"Recognition Imaging with a DNA Aptamer" Lin, L.; Wang, H.; Liu, Y.; Yan, H.; Lindsay, S. M., Biophys. J. 90, 4236-4238 (2006).
[Publication]
"Conductance of a biomolecular wire", Visoly-Fisher, I.; Daie, K.; Terazono, Y.; Herrero, C.; Fungo, F.; Otero, L.; Durantini, E.; Silber, J. J.; Sereno, L.; Gust, D.; Moore, T. A.; Moore, A. L.; Lindsay, S. M., Proc. Nat. Acad. Sci. 103, 8686-8690 (2006).