Raimund Fromme
Assistant Research Professional
Faculty Research Associate
Dr. , Technical University Berlin , Photosynthesis, 1994
Home Department Chemistry and Biochemistry
Areas of Study X-ray Crystallography+++ Light Harvesting +++ Electron transfer + F-Type ATPase +Sugar binding proteins Photosynthesis
Link Personal Homepage


Background The inner sanctum of Photosynthesis the structure and function of Photosystem I and II is since my master thesis and Ph.D. the fundament of my research interest. Since four years I have the opportunity to work on crystal structures of various proteins in the broad field of photosynthesis. The membrane proteins are the most interesting and challenging proteins at all. Currently the protein data bank has above 50,000 structures, in contrast the number of known membrane protein structures is still around at 150. Therefore the most important proteins are in their majority still unknown by their structure, beside the fact that the numeric share is at least one third of all proteins. The field of membrane protein structure determination is still in the beginning with a clear growing impact to many research topics in chemistry, biochemistry and biology.

The potential anti-HIV acting protein Cyanovirin-N with several mutations was crystallized and the structure determined to 1.8 Angstrom (pdb 2PYS).For details see Fromme, R. Katilene,Z. Giomarelli,B. Bogani,F. McMahon, J. Mori, T. , Fromme, P. Ghirlanda, G. BIOCHEMISTRY(2007) 46,9199-9207.

Refinement of an electron density map from C-phycocyanin from Galdieria sulphuraria. Depicted is the refined ligand.See structure in the protein data bank(pdb) code 3BRP.

Conformational gating of dimannose binding to the antiviral protein cyanovirin revealed from the crystal structure at 1.35 Angstrom resolution Raimund Fromme, Zivile Katiliene, Petra Fromme, and Giovanna Ghirlanda Protein Science (2008), 17:939-944.
RaimundPic1.jpg
Raimund Fromme
University of Sydney
School of Biology
Research Fellow 2009

phone: (480)965-8040
phone: (480)332-7496 cell
fax: (480)965-2747
email: Raimund.Fromme
@asu.edu
[Publication] 1.) Fromme, R. Katilene,Z. Giomarelli,B. Bogani,F. McMahon, J. Mori, T. , Fromme, P. Ghirlanda, G. BIOCHEMISTRY(2007) 46,9199-9207. A Monovalent Mutant of Cyanovirin-N Provides Insight Into the Role of Multiple Interactions with gp120 for Antiviral Activity
[Publication] 2.)Fromme,R. Grotjohann, I. and P. Fromme (2008) in: Primary Processes in Photosynthesis ,Part 2(G.Renger ed.) Royal Society of Chemistry Cambridge, UK) , Structure and Function of Photosystem I, 111-146
[Publication] 3.)Fromme,R. Grotjohann, I. and P. Fromme (2006) in: Structural Biology of membrane proteins (S. Buchanan, R. Grisshammer eds) Royal Society of Chemistry Cambridge, UK) pp. 320-348 Structure of Photosystems I and II
[Publication] 4.)Spetzler D, York J, Daniel D, Fromme R, Lowry D, Frasch W,BIOCHEMISTRY 45 (10): 3117-3124(2006) Microsecond time scale rotation measurements of single F-1-ATPase molecules